Naeem Erfani Majd
Shahid Chamran University, Iran
Title: Histomorphometrical effects of Sesame on young and old rat prostate
Biography
Biography: Naeem Erfani Majd
Abstract
Androgens are required to maintain the integrity of the prostate and the survival of androgen dependent epithelial cells within the gland. Anti-androgens are the primary treatment strategy for non-localized prostate cancer, but ultimately fail over time with the development of androgen independent tumors. Estrogens affect the growth and development of the prostate and may affect the development of prostate cancer. Because of the side effects of estrogen treatment alternative therapies include the use of phytoestrogens as chemo-preventative and chemotherapeutic treatment modalities. A number of phytoestrogens have been shown to have anti-androgenic effects and anti-oxidant activities. Sesame seeds contain phytoestrogens and antioxidant agents which can affect the prostate. As a regard, this study was taken to evaluate the effect of sesame seed on the histomorphometry of prostate gland in young and aged rats. For this purpose, 20 young and 20 aged rats were selected and each one was divided into 2 groups. Control groups, which feed by pellets (28 grams) for 2 periods of 30 and 60 days. Treatment groups, which feed by 8.5-gram sesame seed and 19.5-gram food pellets for 30 days and 60 days. At the end of experiment, ventral lobe of the prostate glands were removed. The 5-6 µm sections were made using paraffin embedding technique and stained by H&E. Levels of blood testosterone were measured also. The results showed that the epithelium thickness of secretory units were increased significantly in ventral lobe of young rats prostate which feed by sesame seed. The secretory units number and diameter of the old rats were decreased significantly, and they were crushed and collapsed with numerous fold in lumen. The number, thickness and folds of secretory units were decreased significantly. The secretory cells were seen as squamous with elongated and heterochromatin nucleus. The testosterone level was increased only in young rat which feed by sesame for 60 days. Calculation: The sesame seed intense the prostate regression in old rat.